Molecular mechanisms of postmenopausal osteoporosis
نویسندگان
چکیده
منابع مشابه
Mechanisms of action of antiresorptive therapies of postmenopausal osteoporosis.
In the treatment of osteoporosis, the aim of the antiresorptive therapy is to restore bone density by decreasing bone remodeling. The process of bone remodeling plays a role in plasma calcium homeostasis and serves to modify bone architecture in order to meet changing mechanical needs, to maintain osteocyte viability, and to repair microdamage in bone matrix. Estrogen deficiency results in a nu...
متن کاملIn silico analysis of the molecular mechanism of postmenopausal osteoporosis
Postmenopausal osteoporosis (PO) is a common disease in females >50 years of age worldwide and is becoming an increasing burden to society. The present study aimed to assess the molecular mechanism of PO using bioinformatic methods. The gene expression data from patients with PO and normal controls were downloaded from the ArrayExpress database provided by European Bioinformatics Institute. Fol...
متن کاملManagement of postmenopausal osteoporosis.
Postmenopausal osteoporosis is associated with significant morbidity, mortality, reduction in quality of life, and increasing health care costs. It is estimated that 1.5 million women in the United States have one or more osteoporosis-related fractures annually. Fractures may occur at any site, but vertebral fractures are the most common. Longitudinal studies have demonstrated a decreased life ...
متن کاملTreatment of postmenopausal osteoporosis.
The aim of treatment of postmenopausal osteoporosis is to reduce the frequency of vertebral and non-vertebral fractures (especially at the hip), which are responsible for morbidity associated with the disease. Results of large placebo controlled trials have shown that alendronate, raloxifene, risedronate, the 1-34 fragment of parathyroid hormone, and nasal calcitonin, greatly reduce the risk of...
متن کاملAn Overview of Postmenopausal Osteoporosis
Osteoporosis is the outcome of a group of diseases with diverse etiology of which post menopausal variety makes up a significant share. Consensus Development Conference defined osteoporosis as “a systemic skeletal disease characterized by low bone mass and microarchitectural deterioration with a consequent increase in bone fragility and susceptibility to fracture”1. It has been operationally de...
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ژورنال
عنوان ژورنال: Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
سال: 2009
ISSN: 0300-9173
DOI: 10.3143/geriatrics.46.117